January 16, 2025
1 min read
Key takeaways:
- Real-world Omni outcomes showed reductions in IOP and medication use in primary open-angle glaucoma or ocular hypertension.
- Outcomes were independent of cataract surgery.
Stand-alone canaloplasty and trabeculotomy with the Omni surgical system showed positive real-world outcomes in reducing IOP and medication use, according to a study published in American Journal of Ophthalmology.
“This study is both significant and unique, given its real-world design and considerably larger scale compared to previous studies on stand-alone canaloplasty and trabeculotomy with Omni,” Jaime Dickerson, vice president of medical and clinical affairs at Sight Sciences, told Healio. “It offers strong evidence reaffirming the long-term effectiveness of stand-alone Omni in managing primary open-angle glaucoma, with sustained reductions in intraocular pressure and decreased reliance on medications.”
The retrospective clinical cohort study used the IRIS Registry to investigate 230 eyes of 196 patients with primary open-angle glaucoma (POAG) or ocular hypertension with known laterality. Forty percent of eyes had mild POAG and 41.3% had severe POAG, while 66.5% were pseudophakic. Eyes with concomitant cataract surgery were excluded from the study.
Over 36 months of follow-up, mean IOP ranged from 15.1 mm Hg to 16.7 mm Hg compared with 22.1 mm Hg at baseline (P < .0001), with average eye-level reductions ranging from 5.6 mm Hg to 7.1 mm Hg. The mean number of glaucoma medications decreased from 2.1 at baseline to a range of 1.1 to 1.8 medication classes over 36 months. These reductions were statistically significant through 18 months (P .0011).
Through 36 months, eyes with a baseline IOP of less than 18 mm Hg had reductions in medication use, while eyes with a baseline IOP higher than 18 mm Hg had statistically significant reductions in IOP.
According to the study, these results are in line with previous Omni studies, and the reductions in IOP and number of medications compare favorably with reductions seen with gonioscopy-assisted transluminal trabeculotomy, trabecular ablation, excisional goniotomy and ab interno canaloplasty.
“These findings reinforce Omni’s role as a valuable treatment option as a stand-alone procedure, independent of cataract surgery,” Dickerson told Healio.
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