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Ocular diseases impact not only health care spending in the ophthalmologist’s office, but also patients’ productivity and quality of life. This study by Paudel and colleagues found that across 3 countries, productivity costs and the value of quality of life lost were very important to the overall economic impact of late-stage age-related macular degeneration (AMD), even greater … [Read more...] about Holistic Evaluation of the Burden of Eye Disease

To the Editor The study conducted by Hathaway et al demonstrated a potential association between the use of the glucagon-like peptide 1 (GLP-1) receptor agonist semaglutide for both diabetes and weight management and an increased risk of nonarteritic anterior ischemic optic neuropathy (NAION). The authors are to be commended for a well-conducted study and in particular for the … [Read more...] about Considerations Regarding Association of Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy

To the Editor We wish to address several issues in the article titled “Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide” published in JAMA Ophthalmology. … [Read more...] about Considerations Regarding Association of Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy

To the Editor Hathaway et al reported on a relatively high 36-month cumulative incidence of nonarteritic anterior ischemic optic neuropathy (NAION), 8.9% (95% CI, 4.5%-13.1%), among a cohort of semaglutide users (n = 169) with evidence of type 2 diabetes who received care in a neuro-ophthalmology clinic at an academic medical center. Most NAION cases were observed in the first … [Read more...] about Considerations Regarding Association of Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy

To the Editor We commend Hathaway and colleagues on their seminal work describing a potential association between semaglutide, a glucagon-like peptide 1 receptor agonist (GLP-1 RA), and the development of nonarteritic anterior ischemic optic neuropathy (NAION). While the findings are hypothesis generating, the study has some limitations that prevent a definitive conclusion from … [Read more...] about Considerations Regarding Association of Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy

To the Editor I read with great interest the recent study published in JAMA Ophthalmology by Hathaway et al warning of an increased risk of nonarteritic anterior ischemic optic neuropathy (NAION) among patients starting treatment with semaglutide, a glucagon-like peptide 1 receptor agonist (GLP-1 RA), either for type 2 diabetes or for overweight or obesity. Their findings from … [Read more...] about Considerations Regarding Association of Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy

To the Editor We read with interest the article by Hathaway et al and applaud the effort to investigate safety signals of semaglutide. We were, however, concerned that the methods used may suffer from bias. … [Read more...] about Considerations Regarding Association of Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy

This cohort study examines patient data from January 2019 to December 2023 to evaluate national trends in the use of artificial intelligence–based screenings to detect diabetic retinopathy among patients with types 1 or 2 diabetes. … [Read more...] about Use of Artificial Intelligence–Based Detection of Diabetic Retinopathy in the US

Uveitis caused by Mycobacteria tuberculosis remains difficult to diagnose and difficult to treat. Even the recognized tuberculosis uveitis (TBU) phenotypes (choroidal granuloma, retinal vasculitis, serpiginous chorioretinopathy, and granulomatous chronic anterior uveitis) are diverse and not specific to tuberculosis, but tuberculosis can present with almost any uveitic … [Read more...] about Tuberculosis Uveitis—Consumed by Uncertainty

This diagnostic study investigates the predictive accuracy of the Collaborative Ocular Tuberculosis Study (COTS) calculator score 4 and 5 in guiding initiation of antitubercular therapy in patients with clinically suspicious tubercular uveitis. … [Read more...] about COTS Calculator for Tubercular Uveitis